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770-17-2

2-MORPHOLIN-4-YLACETOHYDRAZIDE synthesis

2synthesis methods
-

Yield:770-17-2 95%

Reaction Conditions:

with hydrazine in ethanol at 90; for 18 h;

Steps:

85.A Synthesis of 3-(6-Methoxynaphthalen-2-yl)-5-(5-Morpholin-4-Ylmethyl-1H-[1,2,4]Triazol-3-yl)-1H-Indazole (CC001)

A. Morpholin-4-yl-acetic acid hydrazide A solution of methyl morpholinoacetate (2.43 g, 15.3 mmol), ethanol (20 mL) and hydrazine (0.53 mL, 16.8 mmol) was stirred at 90° C. for 18 hours. The mixture was concentrated and dried to provide the title compound (2.30 g, 95%): ES-MS (m/z) 160 [M+1]+

References:

US2005/107386,2005,A1 Location in patent:Page/Page column 46

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