2-N-Boc-2-aMino-N-MethylacetaMide synthesis

6synthesis methods

Product Name:2-N-Boc-2-aMino-N-MethylacetaMide
CAS Number:88815-85-4
Molecular formula:C8H16N2O3
Molecular Weight:188.22

Carbamic acid, [(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester (9CI)

109522-21-6
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88815-85-4
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$110.00/1g

Yield:88815-85-4 86%

Reaction Conditions:

with terephthalonitrile;water in acetonitrile at 20; for 24 h;Catalytic behavior;Inert atmosphere;Irradiation;Reagent/catalyst;

Steps:

4.2. Photoreaction of 1 with DCN

General procedure: An aqueous CH₃CN solution (CH₃CN 90 mL, H₂O 10 mL) of N-Boc phenylalanine or tyrosine amides 1 (10 mM), and DCN (10 mM) in Pyrex vessels (18 mm 180 mm) was purged with Ar for 10 min. The mixture was irradiated with 100 W high-pressure mercury lamp for 24 h, and then the solvent was removed under reduced pressure. The crude product was purified by silica-gel column chromatography using hexane/EtOAc as the eluents to give N-Boc-glycine derivatives 2. The photoreactions of dipeptides 3, 5 were also carried out similarly.

References:

Yamawaki, Mugen;Okita, Yoshiki;Yamamoto, Takashi;Morita, Toshio;Yoshimi, Yasuharu [Tetrahedron,2017,vol. 73,# 51,p. 7239 - 7244]

4530-20-5 Synthesis