2-(N-HEXADECANOYLAMINO)-4-NITROPHENOL synthesis

Yield:60301-87-3 25 g (80%)

Reaction Conditions:

in pyridine;chloroform;water;toluene;

Steps:

1.a EXAMPLE 1

(a) To a solution of 12.3 g (80 mmol) of 2-amino-4-nitrophenol in 190 ml pyridine was added with stirring at 25° C 22.6 g (82 mmol) of palmitoyl chloride. After 72 hours at room temperature the pyridine was removed under reduced pressure. The last traces of pyridine were distilled with toluene (twice 50 ml) and the residue dried at 40° C (0.1 mm Hg, 4 hr). The product was scraped off the flask and was stirred for 2 hours with 600 ml of water and then filtered. The residue was dried and recrystallized from 2 liters of chloroform. Yield 25 g (80%) of 2'-hydroxy-5'nitrohexadecananilide; mp 146°-148° C.

References:

US4082781,1978,A