2-NAPHTHALENAMINE, 6-METHYL- synthesis

7synthesis methods

Product Name:2-NAPHTHALENAMINE, 6-METHYL-
CAS Number:37796-79-5
Molecular formula:C11H11N
Molecular Weight:157.21

7499-66-3 Synthesis

7499-66-3
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75-16-1
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37796-79-5
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Yield:37796-79-5 81%

Reaction Conditions:

with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran at 90;Inert atmosphere;

Steps:

1

General procedure: Under the protection of nitrogen, dissolve S1 (15mmol, 3330mg) in 60mL THF, slowly add methylmagnesium bromide (1M inTHF, 60mL), [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride It was dissolved in 30mL THF and slowly added dropwise to the reaction. After the end, the temperature was raised to 90°C. After the completion of the reaction was detected by TLC, saturated ammonium chloride was added for quenching, extracted with ethyl acetate, the organic phases were combined and dried with anhydrous sodium sulfate, the solvent was removed by rotary evaporation to obtain the residue, which was subjected to flash column chromatography (eluent: PE:EA=6:1) 1.9g of brown solid product S2 was obtained with a yield of 81%.

References:

CN111517964,2020,A Location in patent:Paragraph 0081; 0097-0099

7499-66-3 Synthesis

7499-66-3
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$19.00/1g

676-58-4 Synthesis