ChemicalBook CAS DataBase List 2-Nitro-1-phenylpropane

2-Nitro-1-phenylpropane synthesis

10synthesis methods

Product Name:2-Nitro-1-phenylpropane
CAS Number:17322-34-8
Molecular formula:C9H11NO2
Molecular Weight:165.19

705-60-2 Synthesis

705-60-2
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17322-34-8
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Yield:17322-34-8 99%

Reaction Conditions:

with formic acid;dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer;triethylamine;N-tosylethylenediamine in ethyl acetate at 28; for 0.5 h;chemoselective reaction;

Steps:

4.2. General procedure for the transfer hydrogenation of conjugated nitroalkenes

General procedure: A mixture of the TsEN ligand (0.0044 mmol), [RhCl₂Cp^*]₂ (0.002 mmol), and triethylamine (11 μL, 0.08 mmol) was dissolved in1 mL methanol and heated at 70 °C for 1 h in a glass tube. After cooling down, the solvent was removed in vacuo. Nitroalkene substrate (0.4 mmol) in EtOAc (1.0 mL) and the azeotrope of formic acid/triethylamine (0.2 mL) were added in turn. The mixture was stirred at 28 °C for the corresponding time. After completion, the solution was washed with water. The aqueous layer was extracted with EtOAc (5 mL×3). The combined organic layer was dried over Na₂SO₄, filtered, and concentrated under reduced pressure to afford the crude product, which was purified by flash chromatography (PE/EtOAc) on silica gel to provide the pure reduction product.

References:

Xiang, Jing;Sun, Er-Xiao;Lian, Chun-Xia;Yuan, Wei-Cheng;Zhu, Jin;Wang, Qiwei;Deng, Jingen [Tetrahedron,2012,vol. 68,# 24,p. 4609 - 4620] Location in patent:experimental part

705-60-2 Synthesis

705-60-2
219 suppliers
$10.00/1g

17322-34-8
21 suppliers
inquiry