![](/CAS/20150408/GIF/1448988-13-3.gif)
2-nitro-5-(pyrrolidin-1-yl)pyridine synthesis
- Product Name:2-nitro-5-(pyrrolidin-1-yl)pyridine
- CAS Number:1448988-13-3
- Molecular formula:C9H11N3O2
- Molecular Weight:193.2
![Pyrrolidine](/CAS/GIF/123-75-1.gif)
123-75-1
536 suppliers
$10.00/5g
![5-Bromo-2-nitropyridine](/CAS/GIF/39856-50-3.gif)
39856-50-3
525 suppliers
$6.00/5g
![2-nitro-5-(pyrrolidin-1-yl)pyridine](/CAS/20150408/GIF/1448988-13-3.gif)
1448988-13-3
12 suppliers
inquiry
Yield:1448988-13-3 410 mg
Reaction Conditions:
at 120; for 1 h;Microwave irradiation;
Steps:
25.1 Step 25.1 : 2-Nitro-5-pyrrolidin-1 -ylpyridine
Step 25.1 : 2-Nitro-5-pyrrolidin-1 -ylpyridine A mixture of 600 mg (2.93 mmol) of 5-bromo-2-nitropyridine and 1 .05 g (14.63 mmol) of pyrrolidine is heated in a Biotage microwave machine for 1 hour at 120°C. The reaction medium is diluted with water and then extracted with ethyl acetate. The organic phase is washed twice with water, dried over MgS04 and then filtered. The filtrate is evaporated under reduced pressure and then chromatographed on silica gel, eluting with a heptane/ethyl acetate mixture from (100/0 v/v) up to (50/50 v/v) to give 410 mg of 2- nitro-5-pyrrolidin-1-ylpyridine.
References:
WO2013/111106,2013,A1 Location in patent:Page/Page column 113