2-nitro-5-(pyrrolidin-1-yl)pyridine synthesis

Yield:1448988-13-3 410 mg

Reaction Conditions:

at 120; for 1 h;Microwave irradiation;

Steps:

25.1 Step 25.1 : 2-Nitro-5-pyrrolidin-1 -ylpyridine

Step 25.1 : 2-Nitro-5-pyrrolidin-1 -ylpyridine A mixture of 600 mg (2.93 mmol) of 5-bromo-2-nitropyridine and 1 .05 g (14.63 mmol) of pyrrolidine is heated in a Biotage microwave machine for 1 hour at 120°C. The reaction medium is diluted with water and then extracted with ethyl acetate. The organic phase is washed twice with water, dried over MgS0₄ and then filtered. The filtrate is evaporated under reduced pressure and then chromatographed on silica gel, eluting with a heptane/ethyl acetate mixture from (100/0 v/v) up to (50/50 v/v) to give 410 mg of 2- nitro-5-pyrrolidin-1-ylpyridine.

References:

WO2013/111106,2013,A1 Location in patent:Page/Page column 113