![](/CAS/GIF/88-73-3.gif)
2-Nitrochlorobenzene synthesis
- Product Name:2-Nitrochlorobenzene
- CAS Number:88-73-3
- Molecular formula:C6H4ClNO2
- Molecular Weight:157.55
![2-Nitrotoluene](/CAS/GIF/88-72-2.gif)
88-72-2
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$15.00/25g
![2-Nitrochlorobenzene](/CAS/GIF/88-73-3.gif)
88-73-3
8 suppliers
$16.00/25g
Yield:88-73-3 86.1%
Reaction Conditions:
with bromine;iodine;chlorine at 140; for 2 h;Reagent/catalyst;Temperature;
Steps:
32 Example 32
In a 1000 ml four-necked round bottom flask, 312.56 g o-nitrotoluene and a quantitative catalyst (a mixture of 10: 1 mass ratio of bromine and elemental iodine) were added. The mass ratio of o-nitrotoluene to the catalyst was controlled at1: 0.08,235r / min speed stirring and heated to 140 ° C, slowly into the chlorine gas, two hours after the sample, with gas chromatography tracking reaction by-products o-nitrobenzylidene chloride to 5%O-nitrotoluene conversion of 41%, the reaction was stopped; After completion of the reaction, the degree of vacuum -0.098MPa, vacuum distillation at a temperature of 109 deg.] C, recovering nitrotoluene, continued use of chlorinated cyclic;The residue after recovery of o-nitrotoluene was recrystallized from petroleum ether to obtain o-nitrochlorobenzyl chloride as a white crystalline solid.
In this example, the production effect of 99.2% of o-nitrochlorobenzyl chloride and 86.1% of yield (based on the actual consumed o-nitrotoluene) was achieved.
References:
Sichuan Fusida Biotechnology Development Co., Ltd.;Liu, Hu;Wang, Wen;Ma, Qingwei;Chen, Xi;Li, Zhou;Zhang, Hua;Wang, Lei CN106008348, 2016, A Location in patent:Paragraph 0119; 0120
![2-Chloroaniline](/CAS/GIF/95-51-2.gif)
95-51-2
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$5.00/5 g
![2-Nitrochlorobenzene](/CAS/GIF/88-73-3.gif)
88-73-3
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$16.00/25g
![1-Bromo-2-nitrobenzene](/CAS/GIF/577-19-5.gif)
577-19-5
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$14.00/5g
![2-Nitrochlorobenzene](/CAS/GIF/88-73-3.gif)
88-73-3
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$16.00/25g
![2-Nitrobenzoic acid](/CAS/GIF/552-16-9.gif)
552-16-9
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$10.00/10g
![2-Nitrochlorobenzene](/CAS/GIF/88-73-3.gif)
88-73-3
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$16.00/25g
![2-Chlorophenylboronic acid](/CAS/GIF/3900-89-8.gif)
3900-89-8
377 suppliers
$6.00/1g
![2-Nitrochlorobenzene](/CAS/GIF/88-73-3.gif)
88-73-3
8 suppliers
$16.00/25g