2-Oxazolamine,4-(1-methylethyl)-(9CI) synthesis
- Product Name:2-Oxazolamine,4-(1-methylethyl)-(9CI)
- CAS Number:229003-15-0
- Molecular formula:C6H10N2O
- Molecular Weight:126.16
Yield:229003-15-0 41%
Reaction Conditions:
with sodium hydroxide;sodium acetate;tetra(n-butyl)ammonium hydroxide in tetrahydrofuran;water at 20; for 48 h;
Steps:
A.A8.2
To a solution of 3,3-dimethyl-I-hydroxy-2-butanone (4.0 g) and cyanimide (50% w/w, 2.86 g) in THF (10 mL) was added a 1N NaOAc solution (8 mL), followed by tetra-n-butylammonium hydroxide (0.4 M, 3.6 mL), then a 1N NaOH solution (1.45 mL). The resulting mixture was stirred at room temperature for 2 d. The resulting organic layer was separated, washed with water (3 x 25 mL), and the aqueous layer was extraced with Et2O (3 x 25 mL). The combined organic layers were treated with a 1N NaOH solution until basic, then extracted with CH2Cl2 (3 x 25 mL). The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure to afford 2-Amino-4-isopropyl-1,3-oxazole (1.94 g, 41 %): HPLC ES-MS mlz 141 ((M+H)+).
References:
EP1047418,2005,B1 Location in patent:Page/Page column 26-27
5469-26-1
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