ChemicalBook CAS DataBase List (2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID

(2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID synthesis

6synthesis methods

Product Name:(2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID
CAS Number:945-03-9
Molecular formula:C9H7NO3S
Molecular Weight:209.22

3(2H)-Benzothiazoleacetic acid, 2-oxo-, ethyl ester

951-41-7
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(2-OXO-1,3-BENZOTHIAZOL-3(2H)-YL)ACETIC ACID

945-03-9
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$220.00/500mg

Yield:945-03-9 81%

Reaction Conditions:

with potassium fluoride;tetrabutyl ammonium fluoride in tetrahydrofuran;water at 70; for 7 h;

Steps:

General procedure for ester and acetate hydrolysis

General procedure: To a solution of ester or acetate (1 mmol) in THF (5 mL) was added alkali metal fluoride (2 mmol) followed by quaternary ammonium salt (1 M in THF, 2 mL) and the resultant solution was stirred for 7 h. The reaction mixture was diluted with ethyl acetate (30 mL) and washed with water (2 × 20 mL) followed by brine solution (20 mL). The organic layer was dried over MgSO₄ and concentrated under reduced pressure to get a crude compound, which was triturated with hexane to get the corresponding product in 60-95 % yield.

References:

Vijayalakshmi;Balakrishna;Mustafa, Shaik [Asian Journal of Chemistry,2018,vol. 30,# 2,p. 309 - 311]

934-34-9 Synthesis