ChemicalBook CAS DataBase List 2-OXO-1-OXA-SPIRO[4.5]DECANE-4-CARBOXYLIC ACID

2-OXO-1-OXA-SPIRO[4.5]DECANE-4-CARBOXYLIC ACID synthesis

7synthesis methods

Product Name:2-OXO-1-OXA-SPIRO[4.5]DECANE-4-CARBOXYLIC ACID
CAS Number:2819-56-9
Molecular formula:C10H14O4
Molecular Weight:198.22

ethyl 2-oxo-1-oxaspiro[4.5]decane-4-carboxylate

61858-03-5
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2-OXO-1-OXA-SPIRO[4.5]DECANE-4-CARBOXYLIC ACID

2819-56-9
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$31.00/200μmol

Yield:2819-56-9 91%

Reaction Conditions:

with water;lithium hydroxide in tetrahydrofuran at 20; for 4 h;

Steps:

1

The obtained product V-7 was added to a mixed solution of tetrahydrofuran and water (v/v = 3/1), 2 equivalents of lithium hydroxide solid was added, and the mixture was reacted at room temperature for 4 hours.After completion of the reaction, the reaction mixture was acidified with a 1N aqueous solution of hydrochloric acid, ethyl acetate, and concentrated under reduced pressure to afford product IV-7, yield 91%.

References:

CN108530407,2018,A Location in patent:Paragraph 0043; 0045; 0047

110-17-8 Synthesis