ChemicalBook CAS DataBase List (2-OXOPYRIDIN-1(2H)-YL)ACETIC ACID

(2-OXOPYRIDIN-1(2H)-YL)ACETIC ACID synthesis

7synthesis methods

Product Name:(2-OXOPYRIDIN-1(2H)-YL)ACETIC ACID
CAS Number:56546-36-2
Molecular formula:C7H7NO3
Molecular Weight:153.14

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Yield: 99%

Reaction Conditions:

with lithium hydroxide monohydrate in methanol;water at 20; for 0.333333 h;

Steps:

1.2 Step 2) Synthesis of 2-(2-oxopyridine-1(2H)-yl)acetic acid
Ethyl 2-(2-oxopyridine-1(2H)-yl)acetate (406 mg, 2.24 mmol) In a 50mL single-mouth bottle, Add methanol (5mL), Water (1mL), Further lithium hydroxide monohydrate (115 mg, 2.68 mmol) was added. Stir at room temperature for 20 minutes. Stop the reaction, Concentrated sulfuric acid (131 mg, 1.34 mmol, 98%) was added. Concentrate the reaction solution, Azeotropically distilled three times with toluene, The title compound was obtained as a white solid (343 mg, 99%).

References:

Guangdong Dongyangguang Pharmaceutical Co., Ltd.;Xu Tengfei;Jin Chuanfei;Zhong Wenhe;Xue Yaping CN109761892, 2019, A Location in patent:Paragraph 0213; 0219-0220

142-08-5 Synthesis