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350988-64-6

2-P-TOLYL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE synthesis

3synthesis methods
2-p-Tolyl-quinoline-4-carboxylic acid ethyl ester

80221-41-6
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2-P-TOLYL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE

350988-64-6
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Yield:350988-64-6 90%

Reaction Conditions:

with hydrazine hydrate in ethanol;Reflux;

Steps:

Synthesis of compounds (8a-f).

General procedure: A solution of the isolated esters 7a-f(10 mmol) in ethanol (20 mL), hydrazine hydrate (97 %, 3 mL) was added and heated under reux for 5-8 h. After cooling, the formed precipitate was ltered off, washed with water, dried, and crystallized from ethanol

References:

Abbas, Samar H.;Abd El-Hafeez, Amer Ali;Shoman, Mai E.;Montano, Monica M.;Hassan, Heba A. [Bioorganic Chemistry,2019,vol. 82,p. 360 - 377] Location in patent:supporting information