![](/CAS/GIF/252723-21-0.gif)
2-PIPERIDIN-3-YLPROPAN-2-OL synthesis
- Product Name:2-PIPERIDIN-3-YLPROPAN-2-OL
- CAS Number:252723-21-0
- Molecular formula:C8H17NO
- Molecular Weight:143.23
![tert-butyl 3-(2-hydroxypropan-2-yl)piperidine-1-carboxylate](/CAS/20180629/GIF/914654-74-3.gif)
914654-74-3
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![2-PIPERIDIN-3-YLPROPAN-2-OL](/CAS/GIF/252723-21-0.gif)
252723-21-0
24 suppliers
$90.00/50mg
Yield:252723-21-0 100%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 1 h;
Steps:
Step-2 Synthesis of 2-(piperidin-3-yl)propan-2-ol (Intermediate AA168-3)
To a solution of Intermediate AA168-2 (5.0 g, 20.57 mmol) in DCM (50 mL) was added trifluoroacetic acid (5 mL). After stirring at RT for 1 h, the reaction mixture was concentrated under reduced pressure, diluted with sodium bicarbonate solution, and extracted with ethyl acetate (3×40 mL). The combined organic layer was washed with brine solution, dried over sodium sulfate, and concentrated under reduced pressure to afford Intermediate AA168-3 (5.0 g, quantitative %). MS (ES): m/z 144.1 [M+H]+.
References:
US2021/78996,2021,A1 Location in patent:Paragraph 0901; 0903
![2-(2-BroMo-pyridin-3-yl)-propan-2-ol](/CAS/20150408/GIF/CB72676051.gif)
909532-39-4
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![2-PIPERIDIN-3-YLPROPAN-2-OL](/CAS/GIF/252723-21-0.gif)
252723-21-0
24 suppliers
$90.00/50mg
![Methyl N-Boc-piperidine-3-carboxylate](/CAS/GIF/148763-41-1.gif)
148763-41-1
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![2-PIPERIDIN-3-YLPROPAN-2-OL](/CAS/GIF/252723-21-0.gif)
252723-21-0
24 suppliers
$90.00/50mg