ChemicalBook CAS DataBase List 2-(piperidin-4-yl)thiazole-4-carbaldehyde

2-(piperidin-4-yl)thiazole-4-carbaldehyde synthesis

4synthesis methods

Product Name:2-(piperidin-4-yl)thiazole-4-carbaldehyde
CAS Number:1003639-36-8
Molecular formula:C9H12N2OS
Molecular Weight:196.27

TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

869901-02-0
38 suppliers
$400.00/1g

2-(piperidin-4-yl)thiazole-4-carbaldehyde

1003639-36-8
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Yield:1003639-36-8 86%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 1 h;Temperature;

Steps:

8.1; 9.1 Step 1: Preparation of 2-(piperidin-4-yl) thiazole-4-carbaldehyde

To a solution of tert-butyl 4-(4-formylthiazol-2-yl) piperidine-1-carboxylate (0.5 g, 1.687 mol) in dichloromethane (10 ml), trifluoro acetic acid (5.20 ml , 67.5 mol) was added.The reaction mixture was stirred at room temperature for lb. The reaction mixture was concentrated under reduced pressure toobtain 2-(piperidin-4-yl) thiazole-4-carbaldehyde (0.285 g, 1.451 mmol, 86% yield). MS: m/z = 197.00 [M+1].

References:

WO2018/193387,2018,A1 Location in patent:Page/Page column 101; 102

1,1-Dimethylethyl 4-[4-(ethoxycarbonyl)-2-thiazolyl]-3,6-dihydro-1(2H)-pyridinecarboxylate

922516-53-8
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1003639-36-8
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tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate

365413-31-6
58 suppliers
$55.00/50mg

1003639-36-8
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References

TERT-BUTYL 4-[4-(HYDROXYMETHYL)-1,3-THIAZOL-2-YL]PIPERIDINE-1-CARBOXYLATE

864068-79-1
32 suppliers
$156.00/50mg

1003639-36-8
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References