2-[(propan-2-yl)amino]cyclohexan-1-ol synthesis
- Product Name:2-[(propan-2-yl)amino]cyclohexan-1-ol
- CAS Number:69592-28-5
- Molecular formula:C9H19NO
- Molecular Weight:157.25
Yield:69592-28-5 95%
Reaction Conditions:
with calcium bistrifluoroacetate in neat (no solvent) at 60; for 31 h;regioselective reaction;
Steps:
2. 2. Experimental Procedure
General procedure: Aminolysis of cyclohexene oxide 1 by aniline: in ascrew-capped vial equipped with a magnetic stirrer, Ca(CF3CO2)2 (30 mg, 5 mol%) (freshly prepared using our previously published method)16 was added to aniline (0.190g, 2.04 mmol) and cyclohexene oxide (0.196 g, 2.0 mmol).The resulting mixture was left under vigorous stirring at 40 °C for 31 h and was extracted with AcOEt (2 × 10 mL).The combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the desired product. All the spectroscopic data of the products were compared with those reported in the literature.
References:
Outouch, Rachid;Rauchdi, Mariem;Boualy, Brahim;El Firdoussi, Larbi;Roucoux, Alain;Ali, Mustapha Ait [Acta Chimica Slovenica,2014,vol. 61,# 1,p. 67 - 72]
