2-Propanone, 1-(4-piperidinyl)- (9CI) synthesis

Yield: 95%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20;

References:

Prati, Federica;Zuccotto, Fabio;Fletcher, Daniel;Convery, Maire A.;Fernandez-Menendez, Raquel;Bates, Robert;Encinas, Lourdes;Zeng, Jingkun;Chung, Chun-Wa;De Dios Anton, Paco;Mendoza-Losana, Alfonso;Mackenzie, Claire;Green, Simon R.;Huggett, Margaret;Barros, David;Wyatt, Paul G.;Ray, Peter C. [ChemMedChem,2018,vol. 13,# 7,p. 672 - 677] Location in patent:supporting information