2-Propenoic acid, 3-(5-broMo-2-thienyl)- synthesis

Yield:29079-97-8 72.3%

Reaction Conditions:

with pyridine for 2 h;Reflux;

Steps:

1 Example 1

Preparation of Aromatic Heterocyclic Acrylic Compounds Taking 5-bromothiophene-2-carbaldehyde as the reactant to synthesize 5-bromothiophene-2acrylic acid as an example:Dissolve 382.1 mg (2.0 mmol) of 5-bromothiophene-2-carbaldehyde in 12 mL of pyridine, add 0.26 mL (about 4 mmol) of malonic acid, heat under reflux for 2 hours, slowly drop 3M hydrochloric acid into the mixture until the precipitation is complete, filter with suction , the filter cake was washed with cold water and dried in vacuo to obtain 336.9 mg of 5-bromothiophene-2-acrylic acid with a yield of 72.3%.

References:

CN114573502,2022,A Location in patent:Paragraph 0051-0055