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2-PROPENOIC ACID, 3-(6-CHLORO-3-PYRIDINYL)-, (E)- synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 1.) NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, methanol, water, 5 deg C, 2.) 35 deg C
2: 4 N KOH / ethanol / Heating

References:

Nishikawa;Shindo;Ishii;Nakamura;Kon;Uno [Journal of Medicinal Chemistry,1989,vol. 32,# 3,p. 583 - 593]