2-Propynenitrile, 3-phenyl- (9CI) synthesis
- Product Name:2-Propynenitrile, 3-phenyl- (9CI)
- CAS Number:935-02-4
- Molecular formula:C9H5N
- Molecular Weight:127.14
78-67-1
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Yield: 96%
Reaction Conditions:
with Cu-MOF in acetonitrile at 90; for 9 h;
Steps:
3.1-3.5 Example 3: Cu-MOF catalytic material prepared in Example 2 catalyzed 2,2-azobisisobutyronitrile and phenylacetylene
(1) Benzene acetylene (0.102 g, 1 mmol) and 2,2-azobisisobutyronitrile (0.246 g 1.5 mmol) were weighed in a round bottom flask, and a magnetic charge and a solvent acetonitrile (CH3CN, 5 mL) were added;(2) adding an anionic skeleton Cu-MOF (0.059 g, 0.1 mmol) to the (1) reaction system as a catalyst;(3) then the reaction system (2) is heated at 90 ° C for 9h;(4) After completion of the reaction, it was quenched with water (3), extracted with dichloromethane (DCM) three times, and the organic phase was dried over anhydrous sodium sulfate.Dry, filter, spin dry;(5) Ethyl acetate/petroleum ether was used as a mobile phase, and purified by column chromatography (2), and the isolated yield was 96%.
References:
Zhongyuan University of Technology;Huang Chao;Mi Liwei;Wang Dandan;Wu Jiarui;Zhu Kaifang;Li Gaoxiang;Xu Yupei;Zhang Miaomiao CN109369689, 2019, A Location in patent:Paragraph 0031
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935-02-4
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935-02-4
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