2-[(PYRIDIN-3-YLMETHYL)-AMINO]-ETHANOL synthesis

3synthesis methods

Product Name:2-[(PYRIDIN-3-YLMETHYL)-AMINO]-ETHANOL
CAS Number:70206-51-8
Molecular formula:C8H12N2O
Molecular Weight:152.19

500-22-1 Synthesis

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141-43-5 Synthesis

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70206-51-8
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Yield:70206-51-8 936 mg

Reaction Conditions:

Stage #1: 3-pyridinecarboxaldehyde;ethanolamine in methanol at 60; for 2 h;
Stage #2: with methanol;sodium tetrahydroborate at 60; for 2 h;Cooling with ice;

Steps:

56.56-1 Example 56 (56-1) 2-[(Pyridine-3-ylmethyl) Amino] Ethanol (Example Compound 56-1)

2-Aminoethanol (400 mg)Is dissolved in methanol (10 mL) andAdd 3-pyridinecarbaldehyde (702 mg) and addThe mixture was stirred at 60 ° C. for 2 hours. Sodium borohydride (248 mg) was added to the mixed solution under ice-cooling, and thenThe mixture was stirred at 60 ° C. for 5 hours.After the reaction solution was brought to room temperature, the reaction solution was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (chloroform: methanol = 100: 0 to 95: 5) to give the title compound (936 mg) as a pale yellow oil.

References:

JP2021/80183,2021,A Location in patent:Paragraph 0693-0695

Ethanol, 2-[(3-pyridinylmethylene)amino]-

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70206-51-8
20 suppliers
$45.00/25mg

References

500-22-1 Synthesis

500-22-1
464 suppliers
$6.00/5g

70206-51-8
20 suppliers
$45.00/25mg

References