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2-Pyridineacetic acid, 3-hydroxy-, ethyl ester synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 91.1 percent / H2SO4/H2O (1:1) / 20 h / 130 °C
2: 73 percent / HCl gas / 1.5 h / Heating

References:

Desideri;Manna;Stein;et al. [European Journal of Medicinal Chemistry,1983,vol. 18,# 4,p. 295 - 299]