2-PYRIDINEETHANOL, 6-BROMO-A,A-DIMETHYL- synthesis
- Product Name:2-PYRIDINEETHANOL, 6-BROMO-A,A-DIMETHYL-
- CAS Number:955369-59-2
- Molecular formula:C9H12BrNO
- Molecular Weight:230.1
5315-25-3
456 suppliers
$6.00/5g
67-64-1
6 suppliers
$21.60/10ml
955369-59-2
19 suppliers
$30.00/100mg
Yield:955369-59-2 88%
Reaction Conditions:
Stage #1: 2-bromo-6-methylpyridinewith n-butyllithium;N-ethyl-N,N-diisopropylamine in tetrahydrofuran;hexane at -78 - 0; for 1 h;
Stage #2: acetone in tetrahydrofuran;hexane at -78 - 20; for 2 h;
References:
Lawer, Aggie;Rossi-Ashton, James A.;Stephens, Thomas C.;Challis, Bradley J.;Epton, Ryan G.;Lynam, Jason M.;Unsworth, William P. [Angewandte Chemie - International Edition,2019,vol. 58,# 39,p. 13942 - 13947][Angew. Chem.,2019,vol. 131,# 39,p. 14080 - 14085,6] Location in patent:supporting information