2-Pyrimidinecarbonyl chloride (9CI) synthesis
- Product Name:2-Pyrimidinecarbonyl chloride (9CI)
- CAS Number:220769-83-5
- Molecular formula:C5H3ClN2O
- Molecular Weight:142.54
31519-62-7
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Yield:220769-83-5 99%
Reaction Conditions:
with thionyl chloride in dichloromethane at 40; for 1 h;
Steps:
12.1 Step 1: Synthesis of pyrimidine-2-carbon l chloride
A flask was charged with pyrimidine-2-carboxylic acid (63.2 mg, 0.509 mmol, 1.00 equiv), DCM (5 mL), and thionyl chloride (121 mg, 1.02 mmol, 2.00 equiv). The resulting solution was stirred for 1 h at 40 °C. The resulting mixture was concentrated under reduced pressure to provide 72.0 mg (99% yield) of pyrimidine-2-carbonyl chloride.
References:
WO2019/46318,2019,A1 Location in patent:Paragraph 00225
433214-15-4
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14080-23-0
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