2-(t-Butyldimethylsilyloxy)-6-bromonaphthalene synthesis

3synthesis methods

Product Name:2-(t-Butyldimethylsilyloxy)-6-bromonaphthalene
CAS Number:100751-65-3
Molecular formula:C16H21BrOSi
Molecular Weight:337.33

15231-91-1 Synthesis

15231-91-1
392 suppliers
$7.00/5g

18162-48-6 Synthesis

18162-48-6
668 suppliers
$9.00/5g

2-(t-Butyldimethylsilyloxy)-6-bromonaphthalene

100751-65-3
21 suppliers
$75.00/1g

Yield:100751-65-3 100%

Reaction Conditions:

with 1H-imidazole in dichloromethane at 20; for 2 h;

Steps:

(6-bromonaphthalen-2-yloxy)(f?r*-butyl)dimethylsilane (7)TBSCl (347 mg, 2.3 mmol) was added to a solution of 6-bromonaphthalen-2-ol (446 mg, 2.0 mmol) in dichloromethane (20 ml) followed by the addition of imidazole (272 mg, 4.0 mmol). The reaction mixture was stirred at room temperature for 2 h and then water was added. Organic layer was separated, washed with brine, dried over anhydrous sodium sulfate and evaporated to obtain crude product 7 (680 mg, 100 %), which was pure enough and was used directly for next step. 7:1H NMR (CDCl₃): δ 7.91 (IH, m), 7.55 (3H, m), 7.13 (2H, m), 1.02 (9H, s), 0.25 (6H, s).

References:

WO2008/124812,2008,A1 Location in patent:Page/Page column 48-49

288-32-4 Synthesis

288-32-4
991 suppliers
$5.00/25g

15231-91-1 Synthesis

15231-91-1
392 suppliers
$7.00/5g

100751-65-3
21 suppliers
$75.00/1g

References

288-32-4 Synthesis

288-32-4
991 suppliers
$5.00/25g

15231-91-1 Synthesis

15231-91-1
392 suppliers
$7.00/5g

18162-48-6 Synthesis

18162-48-6
668 suppliers
$9.00/5g

100751-65-3
21 suppliers
$75.00/1g

References