2-(tert-Butyl)-4-chloro-5-nitropyriMidine synthesis

3synthesis methods

Product Name:2-(tert-Butyl)-4-chloro-5-nitropyriMidine
CAS Number:70227-50-8
Molecular formula:C8H10ClN3O2
Molecular Weight:215.64

70227-49-5 Synthesis

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2-(tert-Butyl)-4-chloro-5-nitropyriMidine

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Yield:70227-50-8 92%

Reaction Conditions:

with trichlorophosphate for 5 h;Heating / reflux;

Steps:

O

Synthesis of Compound O.5. A solution of compound O.4 (12 g, 60.9 mmol) in phosphorus oxychloride (96 mL) was stirred at reflux for 5 hr. The reaction mixture was cooled to RT and the excess phosphorus oxychloride was concentrated in vacuo. The residue was added to ice-water and extracted into DCM. The organic layer was dried (Na₂SO₄) and removed in vacuo to afford compound O.5, 2-tert-butyl-4-chloro-5-nitropyrimidine, as a brown liquid (12 g, 92%) which was used without further purification.

References:

US2009/5359,2009,A1 Location in patent:Page/Page column 45

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References

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References