2-tert-Butyl-5-bromopyrimidine synthesis
- Product Name:2-tert-Butyl-5-bromopyrimidine
- CAS Number:85929-94-8
- Molecular formula:C8H11BrN2
- Molecular Weight:215.09
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Yield: 79%
Reaction Conditions:
at 145; for 0.5 h;
Steps:
4.2 Step-2: [00165] Preparation of 5-bromo-2-(tert-butyl)pyrimidine 3:
5-bromo-2-(tert-butyl)pyrimidine-4-carboxylic acid (2, 4.1 g) was heated at 145 C until it melts into brownish liquid (0.5 h). The reaction mixture was diluted with dichloromethane, slurried with silica gel and purified by silica gel column chromatography using 20% ethyl acetate in hexane to afford the title compound 5-bromo-2-(tert-butyl)pyrimidine (3, 2.7 g, 79% yield) as a colorless liquid. Calculated (M+H): 215.01 ; Found (M+H): 215
References:
CADENT THERAPEUTICS;ANDERSON, David, R.;VOLKMANN, Robert, A.;MENNITI, Frank;FANGER, Christopher;XU, Yuelian WO2018/119374, 2018, A1 Location in patent:Paragraph 00165
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