2-(tert-Butylthio)aniline synthesis

Yield:51942-41-7 94%

Reaction Conditions:

with hydrogen in methanol; for 4 h;

Steps:

2 Synthesis of Compound 3 (o-aminophenyl tert-butyl sulfide) of Example 2

4.2 g (0.0199 mol) of compound 2 (o-nitrophenyl tert-butyl sulfide) dissolved in methanol,Nitrogen protection, adding 400mg Raney nickel, under hydrogen conditions,Normal temperature and pressure reaction for 4h,Filtration and concentration of the filtrate gave 3.4 g (0.0188 mol) of compound 3 (o-aminophenyl tert-butyl sulfide), yield 94%

References:

CN109956960,2019,A Location in patent:Paragraph 0063; 0064