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ChemicalBook CAS DataBase List 2-Amino-4-cyclopropylthiazole
324579-90-0

2-Amino-4-cyclopropylthiazole synthesis

3synthesis methods
-

Yield: 100%

Reaction Conditions:

in methanolHeating / reflux;

Steps:

N
EXAMPLE N; 4-Cyclopropyl-thiazol-2-ylamine; A solution of 2-Bromo-1-cyclopropyl-ethanone (CAS [69267-75-0], Indian J. Chem. Sect. B, 22(9), 841(1983) (1 g, 6.1 mmol) and thiourea (0.481 g, 6.1 mmol) in 15 ml of methanol was refluxed overnight. The solvent was evaporated off and the title compound was obtained as an off-white solid (1.38 g, 100%).

References:

Buettelmann, Bernd;Ceccarelli, Simona Maria;Jaeschke, Georg;Kolczewski, Sabine;Porter, Richard Hugh Philip;Vieira, Eric US2006/160857, 2006, A1 Location in patent:Page/Page column 56