ChemicalBook CAS DataBase List 2-THIOPHEN-3-YL-BENZALDEHYDE

2-THIOPHEN-3-YL-BENZALDEHYDE synthesis

5synthesis methods

Product Name:2-THIOPHEN-3-YL-BENZALDEHYDE
CAS Number:99902-03-1
Molecular formula:C11H8OS
Molecular Weight:188.25

872-31-1 Synthesis

872-31-1
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$9.00/1g

40138-16-7 Synthesis

40138-16-7
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$9.00/1g

99902-03-1
46 suppliers
$57.00/100mg

Yield:99902-03-1 211 mg

Reaction Conditions:

with bis-triphenylphosphine-palladium(II) chloride;sodium carbonate in water;acetonitrile at 150; for 0.0833333 h;Sealed tube;Microwave irradiation;

Steps:

35

The microwave vials (20 ml) were equipped with 2-formylphenylboronic acid (290 mg, 2.0 mmol), 3-bromo-thiophene (326 mg,2.0 mmol), and 8 ml of acetonitrile. To the mixture was added 4 ml of an aqueous sodium carbonate solution (1M), followed by the addition of 50 mg of dichlorobis (triphenylYlphosphine) -palladium (II). The reaction vessel was sealed and heated at 150 & lt; 0 & gt; C for 5 minutes with microwave irradiation. After cooling the reaction mixtureExtracted with ethyl acetate. The organic layer was evaporated to provide a crude material which was purified by ISCO to give 211 mg2-thiophen-3-yl-benzaldehyde.

References:

CN104045626,2017,B Location in patent:Paragraph 0324

6165-69-1 Synthesis