2-Thiophenepropanoic acid, β-hydroxy- synthesis
- Product Name:2-Thiophenepropanoic acid, β-hydroxy-
- CAS Number:26359-15-9
- Molecular formula:C7H8O3S
- Molecular Weight:172.2
Yield:26359-15-9 89%
Reaction Conditions:
Stage #1: thiophene-2-carbaldehyde;trimethylsilyl acetatewith trimethylsilyl trifluoromethanesulfonate;N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 2 h;Inert atmosphere;Mukaiyama aldol addition;
Stage #2: with water;trifluoroacetic acid in ethanol;dichloromethane;Inert atmosphere;
References:
Downey, C. Wade;Johnson, Miles W.;Lawrence, Daniel H.;Fleisher, Alan S.;Tracy, Kathryn J. [Journal of Organic Chemistry,2010,vol. 75,# 15,p. 5351 - 5354] Location in patent:supporting information; experimental part
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