2-TRIFLUOROMETHYL-N,N-DIMETHYL-4-NITROANILINE synthesis
- Product Name:2-TRIFLUOROMETHYL-N,N-DIMETHYL-4-NITROANILINE
- CAS Number:54672-09-2
- Molecular formula:C9H9F3N2O2
- Molecular Weight:234.18
400-74-8
213 suppliers
$14.00/25g
124-40-3
496 suppliers
$18.00/100ml
54672-09-2
33 suppliers
$28.60/50MG
Yield:-
Reaction Conditions:
with sodium hydride in tetrahydrofuran at 20 - 50; for 16 h;
Steps:
48
To a solution of 1-floro-4-nitro-2-trifluoromethylbenzene (2.0 g) in tetrahydrofuran (20 mL) were added dimethyamine (0.64 g) and sodium hydride (0.34 g) at room temperature, and this mixture was stirred at 50°C for 16 hours. This reaction mixture was poured into water, and this mixture was extracted with ethyl acetate. This organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.94 g).
References:
EP2133332,2009,A1 Location in patent:Page/Page column 29
777-37-7
294 suppliers
$10.00/5g
124-40-3
496 suppliers
$18.00/100ml
54672-09-2
33 suppliers
$28.60/50MG