![](/CAS/GIF/952182-51-3.gif)
2-(trifluoromethyl)quinoline-6-carboxylic acid synthesis
- Product Name:2-(trifluoromethyl)quinoline-6-carboxylic acid
- CAS Number:952182-51-3
- Molecular formula:C11H6F3NO2
- Molecular Weight:241.17
![tert-butyl 2-(trifluoromethyl)quinoline-6-carboxylate](/CAS/20210305/GIF/1027329-58-3.gif)
1027329-58-3
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![2-(trifluoromethyl)quinoline-6-carboxylic acid](/CAS/GIF/952182-51-3.gif)
952182-51-3
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$312.00/250mg
Yield:952182-51-3 98%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 0 - 20; for 36 h;
Steps:
CA10D
To a solution of tert-butyl 2-trifluoromethylquinoline-6-carboxylate (2 g, 7 mmol) in dichloromethane (50 mL), cooled to 0 0C, was added trifluoroacetic acid (5.18 mL, 67.2 mmol) and the reaction mixture allowed to warm to room temperature and stirred for 36 h. The reaction mixture was concentrated under reduced pressure and the crude product obtained triturated with heptane (4 x 10 mL) to give 2-trifluoromethylquinoline-6-carboxylic acid (1.58 g, 98 %). 1H NMR (400 MHz, CD3OD) δ 7.93 (1 H, d), β.24 (1 H1 d), 8.42 (1H1 dd), 8.73 (1 H1 d), 8.78 (1 H, d). LCMS: Retention time: 1.38 min. MS (ESI) m/z 242 (M + H)+.
References:
WO2008/59370,2008,A2 Location in patent:Page/Page column 66
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![(Trifluoromethyl)trimethylsilane](/CAS/GIF/81290-20-2.gif)
81290-20-2
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![2-(trifluoromethyl)quinoline-6-carboxylic acid](/CAS/GIF/952182-51-3.gif)
952182-51-3
37 suppliers
$312.00/250mg