tert-Butyl (2-((tert-butoxycarbonyl)amino)ethyl)(2-hydroxyethyl)carbamate synthesis
- Product Name:tert-Butyl (2-((tert-butoxycarbonyl)amino)ethyl)(2-hydroxyethyl)carbamate
- CAS Number:200283-08-5
- Molecular formula:C14H28N2O5
- Molecular Weight:304.38
24424-99-5
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$13.50/25G
111-41-1
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$6.00/25g
200283-08-5
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$55.00/100mg
Yield:200283-08-5 100%
Reaction Conditions:
with triethylamine in tetrahydrofuran;ethanol at 20; for 24 h;
Steps:
C52.i C52. i. (2-tert-butoxycarbonylamino-ethyl)-(2-hydroxy-ethyl)-carbamic acid tert-butyl ester:
N-(2-Hydroxyethyl)ethylenediamine (2.06 g; commercial) and TEA (13.8 mL) weredissolved in EtOH (30 mL) and THF (30 mL), di-tert-butyl dicarbonate (10.8 g) was addedand the mixture was stirred at rt for 1 day. TBME and 2M aq. HC1 was added and the org. layer was washed with sat. aq. NaHCO3 and brine, dried over Mg504 and concentrated under reduced pressure. The title compound was obtained as an off-white oil (6.98 g; quant.).M53 (ESI, mlz): 305.01 [M+H]; tR = 0.73 mm.
References:
WO2016/59097,2016,A1 Location in patent:Page/Page column 107
24424-99-5
821 suppliers
$13.50/25G
![Carbamic acid, [2-[(2-hydroxyethyl)amino]ethyl]-, 1,1-dimethylethyl ester (9CI)](/CAS/GIF/208577-84-8.gif)
208577-84-8
18 suppliers
$265.00/100mg
200283-08-5
23 suppliers
$55.00/100mg