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ChemicalBook CAS DataBase List (5-METHYL-4-PHENYL-4 H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID

(5-METHYL-4-PHENYL-4 H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID synthesis

7synthesis methods
Acetic acid, 2-[(5-methyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio]-, 2-[[(ethoxycarbonyl)amino]thioxomethyl]hydrazide

1428354-41-9
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Yield:200815-83-4 72.8%

Reaction Conditions:

Stage #1: 4-ethoxycarbonyl-1-{[(4-phenyl-5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazidewith sodium hydroxide in water; for 2 h;Reflux;
Stage #2: with hydrogenchloride in water;

References:

Popiolek, Ukasz;Kosikowska, Urszula;Dobosz, Maria;Malm, Anna [Journal of Enzyme Inhibition and Medicinal Chemistry,2013,vol. 28,# 3,p. 479 - 488]