3-Methyl-1H-indazole-6-carboxylic acid methyl ester synthesis

8synthesis methods

Product Name:3-Methyl-1H-indazole-6-carboxylic acid methyl ester
CAS Number:201286-95-5
Molecular formula:C10H10N2O2
Molecular Weight:190.2

67-56-1 Synthesis

67-56-1
736 suppliers
$9.00/25ml

201286-96-6 Synthesis

201286-96-6
36 suppliers
$119.00/500mg

3-Methyl-1H-indazole-6-carboxylic acid methyl ester

201286-95-5
20 suppliers
inquiry

Yield:201286-95-5 87%

Reaction Conditions:

with sulfuric acid for 22 h;Heating / reflux;

Steps:

39.4 Preparation Example 39-4 6-(Methoxycarbonyl)-3-methyl-1H-indazole

Preparation Example 39-4 6-(Methoxycarbonyl)-3-methyl-1H-indazole 6-Carboxy-3-methyl-1H-indazole (359 mg, 2.11 mmol) was dissolved in methanol (50 ml), and concentrated sulfuric acid (0.1 ml) was added.. The mixture was heated under reflux for 22 hr.. After cooling, a saturated aqueous sodium hydrogencarbonate solution was added and the methanol was distilled away under reduced pressure.. The residue was extracted with ethyl acetate, and the organic layer was washed with saturated brine and dried over anhydrous sodium sulfate.. The drying agent was filtered off and the filtrate was concentrated under reduced pressure to give the objective compound (340 mg, 87%) as brown crystals. 1H-NMR(CDCl3, δ ppm): 8.18(1H, s), 7.82(1H, d, J=8.4 Hz), 7.72(1H, d, J=8.4 Hz), 3.96(3H, s), 2.61(3H, s).

References:

US6348474,2002,B1 Location in patent:Page column 81