Methanesulfonic acid, 1,1,1-trifluoro-, 3-(1,1-dimethylethyl)phenyl ester synthesis
- Product Name:Methanesulfonic acid, 1,1,1-trifluoro-, 3-(1,1-dimethylethyl)phenyl ester
- CAS Number:201851-06-1
- Molecular formula:C11H13F3O3S
- Molecular Weight:282.28
Yield:201851-06-1 96%
Reaction Conditions:
with pyridine at 0 - 20; for 12 h;
Steps:
9.1 (1) Synthesis of Compound Represented by Formula 9-a
30.0 g (200 mmol) of 3-tert-butylphenol and 150 ml of pyridine were placed in a 500 ml round bottom flask. After cooling down to 0 & lt; 0 & gt; C,101 ml (599 mmol) of trifluoromethanesulfonic anhydride was slowly added dropwise.The temperature was raised to room temperature and stirred for 12 hours.After completion of the reaction, water was added, and the organic layer was extracted with diethyl ether.The organic layer was concentrated under reduced pressure, and then subjected to column purification using ethyl acetate and n-hexane. (54.1 g, 96%).
References:
KR101897044,2018,B1 Location in patent:Paragraph 0488-0489; 0492-0494
![2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE](/CAS/GIF/145100-51-2.gif)
