ChemicalBook CAS DataBase List (S)-3,3-dimethyl-1,7a-dihydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one

(S)-3,3-dimethyl-1,7a-dihydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one synthesis

2synthesis methods

Product Name:(S)-3,3-dimethyl-1,7a-dihydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one
CAS Number:203871-49-2
Molecular formula:C8H11NO2
Molecular Weight:153.18

99208-71-6 Synthesis

(S)-3,3-DiMethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one

99208-71-6
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(S)-3,3-dimethyl-1,7a-dihydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one

203871-49-2
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Yield:203871-49-2 63%

Reaction Conditions:

Stage #1: (5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octanewith bis(2,2,6,6-tetramethyl-1-piperidyl)zinc in 1,4-dioxane;toluene at 0; for 0.166667 h;Inert atmosphere;
Stage #2: with nickel(II) bromide dimethoxyethane;allyl diethyl phosphate in 1,4-dioxane;toluene at 80; for 0.25 h;Inert atmosphere;

References:

Huang, David;Szewczyk, Suzanne M.;Zhang, Pengpeng;Newhouse, Timothy R. [Journal of the American Chemical Society,2019,vol. 141,# 14,p. 5669 - 5674] Location in patent:supporting information

17342-08-4
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$5.00/1g

203871-49-2
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References