ChemicalBook CAS DataBase List Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate

Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate synthesis

6synthesis methods

Product Name:Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate
CAS Number:20443-03-2
Molecular formula:C9H9NO5
Molecular Weight:211.17

138-60-3 Synthesis

138-60-3
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77-76-9
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Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate

20443-03-2
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Yield: 98%

Reaction Conditions:

with hydrogenchloride in methanol;water at 20 - 70; for 17 h;

Steps:

1.a Step a:
Add 10g to the round bottom flask chelidamic acid Add methanol as solvent,Further, 69 mL of 2,2-dimethoxypropane and 6.7 mL of concentrated hydrochloric acid were added to the flask.The reaction temperature was first raised to 70 ° C, refluxed for 4 h, and then reacted at room temperature for 13 h. The initial product was separated through a silica gel column to give Compound 1 in a yield of 98%.

References:

Huazhong University of Science and Technology;Shenzhen Central China University Of Science And Technology Institute;Gan Quan;Ma Chunmiao;Xiong Shu;Wang Yan CN108329259, 2018, A Location in patent:Paragraph 0024; 0047; 0050

67-56-1 Synthesis