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[R-(Z)]-N-[3-(dimethylamino)propyl]-12-hydroxy-9-octadecenamide synthesis

1synthesis methods
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Yield:-

Steps:

1.a EXAMPLE 1

(a) Stage 1: Preparation of γ-Ricinoleamidopropyldimethylamine. 383 g (3.75 moles) of N,N-dimethylaminopropylamine were mixed with 1,043 g of commercial ricinoleic acid (3.5 moles) and heated to 180°-185° C. in a 5 liter reactor. The water of reaction is removed and the reaction is continued until a minimum acid value is attained. The product was then vacuum dried at 100°-105° C. at 50 mm vacuum. The amido-amide intermediate, γ-Ricinoleamidopropyldimethylamine, had the following properties:

References:

US4220581,1980,A