ChemicalBook CAS DataBase List 4-CHLORO-6-IODO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

4-CHLORO-6-IODO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis

6synthesis methods

Product Name:4-CHLORO-6-IODO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
CAS Number:206257-60-5
Molecular formula:C12H9ClINO2
Molecular Weight:361.56

302949-01-5 Synthesis

302949-01-5
19 suppliers
$150.00/500mg

4-CHLORO-6-IODO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

206257-60-5
18 suppliers
inquiry

Yield:206257-60-5 98%

Reaction Conditions:

with trichlorophosphate for 14 h;Heating / reflux;

Steps:

1.c

c) Preparation of 4-chloro-6-iodo-quinoline-3-carboxylic acid ethyl ester A mixture of 6-iodo-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (56 g, 0.16 mol) in phosphorus oxychloride (180 mL) was refluxed under N₂ for 14 h. After cooling, the solvent was removed by rotary evaporator and then by the oil pump. Sat. sodium bicarbonate (200 mL) was slowly added. The solid was collected by filtration, washed with sat. sodium bicarbonate, water and dried to obtain 4-chloro-6-iodo-quinoline-3-carboxylic acid ethyl ester (58 g, 98%) as a yellow solid.

References:

US2006/4046,2006,A1 Location in patent:Page/Page column 12

302949-01-5 Synthesis

302949-01-5
19 suppliers
$150.00/500mg

206257-60-5
18 suppliers
inquiry

References