![](/CAS/GIF/206879-72-3.gif)
4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis
- Product Name:4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS Number:206879-72-3
- Molecular formula:C15H23N3O2
- Molecular Weight:277.36
![TERT-BUTYL 4-(3-NITROPHENYL)PIPERAZINE-1-CARBOXYLATE](/CAS/GIF/206879-94-9.gif)
206879-94-9
13 suppliers
$496.64/5MG
![4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/206879-72-3.gif)
206879-72-3
70 suppliers
$18.00/100mg
Yield: 95%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanolInert atmosphere;
Steps:
1 tert-Butyl 4-(3-aminophenyl)piperazine-l-carboxylate (15d)
To a solution of 15d* (700 mg, 2.27 mmol) in CH3OH (15 mL) was added 10% Pd/C (200 mg) in excess and (g) was passed through latex valve bladder for overnight. The reaction mixture was then filtered through celite and concentrated to afford 15d (600 mg, 95%) as brown viscous liquid which was used in next step without purification.
References:
UNIVERSITY OF HOUSTON SYSTEM;TRUSTEES OF TUFTS COLLEGE;CUNY, Gregory;NIKHAR, Sameer;DEGTEREV, Alexei WO2018/213219, 2018, A1 Location in patent:Paragraph 0178-0179; 0014
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
821 suppliers
$13.50/25G
![4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/206879-72-3.gif)
206879-72-3
70 suppliers
$18.00/100mg
![1-Fluoro-3-nitrobenzene](/CAS/GIF/402-67-5.gif)
402-67-5
266 suppliers
$6.00/5g
![4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/206879-72-3.gif)
206879-72-3
70 suppliers
$18.00/100mg
![tert-Butyl 1-piperazinecarboxylate](/CAS/GIF/57260-71-6.gif)
57260-71-6
734 suppliers
$5.00/5g
![4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/206879-72-3.gif)
206879-72-3
70 suppliers
$18.00/100mg
![1-(3-Nitrophenyl)piperazine](/CAS/GIF/54054-85-2.gif)
54054-85-2
88 suppliers
$17.67/1gm:
![4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/206879-72-3.gif)
206879-72-3
70 suppliers
$18.00/100mg