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ethyl 2-(N-tert-butoxycarbonyl-2,4-pyrrolidinyl)thiazole-4-carboxylate synthesis

4synthesis methods
35150-07-3 Synthesis
D-1-N-Boc-prolinamide

35150-07-3
251 suppliers
$5.00/1g

-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: 99 percent / Lawesson's reagent / tetrahydrofuran / 3.5 h / 20 °C
2.1: KHCO3 / 1,2-dimethoxy-ethane / 0.5 h / 20 °C
2.2: 76 percent / trifluoroacetic anhydride; 2,6-lutidine / 0.5 h / 0 °C

References:

Deng, Shaojiang;Taunton, Jack [Journal of the American Chemical Society,2002,vol. 124,# 6,p. 916 - 917]