methyl 3-hydroxybenzo[b]thiophene-2-carboxylate 1,1-dioxide synthesis

2synthesis methods

Product Name:methyl 3-hydroxybenzo[b]thiophene-2-carboxylate 1,1-dioxide
CAS Number:21211-28-9
Molecular formula:C10H8O5S
Molecular Weight:240.23

methyl 2-[(2-methoxy-2-oxoethyl)sulphonyl]benzoate

26759-41-1
1 suppliers
inquiry

methyl 3-hydroxybenzo[b]thiophene-2-carboxylate 1,1-dioxide

21211-28-9
2 suppliers
inquiry

Yield:-

Reaction Conditions:

with sodium in methanol;water;

Steps:

III.C Stage C.

In a 1 liter flask equipped with an agitator and a reflux and refrigerant there are dissolved 14 g of sodium (0.62 mole) in 500 ml of methyl alcohol. To the solution of sodium methylate obtained, there are added 169 g (0.62 mole) of methyl 2-carbomethoxymethylsulfonyl benzoate. The product dissolves progressively. Agitation is continued constantly for 41/2 hours at room temperature. Then 5 liters of water are added. The methyl 1,1-dioxy-3-hydroxy-thianaphthene-2-carboxylate is then precipitated by the addition of hydrochloric acid.

References:

US3954748,1976,A

2-[(carboxymethyl)sulphonyl]benzoic acid

1209-81-0
2 suppliers
inquiry

21211-28-9
2 suppliers
inquiry

References