(5R)-2-Methylene-5-(1-methylethenyl)cyclohexanol (Mixture of Diastereomers) synthesis

4synthesis methods

Product Name:(5R)-2-Methylene-5-(1-methylethenyl)cyclohexanol (Mixture of Diastereomers)
CAS Number:216655-61-7
Molecular formula:C10H16O
Molecular Weight:152.23

1195-92-2 Synthesis

1195-92-2
53 suppliers
$203.00/100mg

(5R)-2-Methylene-5-(1-methylethenyl)cyclohexanol (Mixture of Diastereomers)

216655-61-7
6 suppliers
$185.00/25mg

Yield:216655-61-7 96%

Reaction Conditions:

Stage #1: (4R)-limonene 1,2-epoxidewith diethyl(2,2,6,6-tetramethylpiperidino)aluminium in hexane;benzene at 0 - 20; for 2.75 h;Yamamoto rearrangement;
Stage #2: with sodium hydrogencarbonate in hexane;benzene at 0;Saturated solution;

References:

Uroos, Maliha;Lewis, William;Blake, Alexander J.;Hayes, Christopher J. [Journal of Organic Chemistry,2010,vol. 75,# 24,p. 8465 - 8470] Location in patent:experimental part

5989-27-5 Synthesis