ChemicalBook CAS DataBase List 2-aMino-2-(3,4-difluorophenyl)ethanol hydrochloride

2-aMino-2-(3,4-difluorophenyl)ethanol hydrochloride synthesis

5synthesis methods

Product Name:2-aMino-2-(3,4-difluorophenyl)ethanol hydrochloride
CAS Number:218449-32-2
Molecular formula:C8H9F2NO
Molecular Weight:173.16

2-Oxazolidinone, 4-(3,4-difluorophenyl)-

225641-91-8
1 suppliers
inquiry

2-aMino-2-(3,4-difluorophenyl)ethanol hydrochloride

218449-32-2
13 suppliers
inquiry

Yield:218449-32-2 87%

Reaction Conditions:

with potassium hydroxide in ethanol;water;

Steps:

c c.

c. (+)-2-Amino-2-(3,4-difluorophenyl)-ethanol To a solution of (+)-4-(3,4-difluorophenyl)-oxazolidin-2-one (1.39 mmol, 0.27 g) in 5.0 mL ethanol was added 5.0 mL of water and pellets of potassium hydroxide (5.0 mmol, 0.28 g). The resulting solution was then heated to reflux overnight. The solvent was removed in vacuo and the resulting residue was extracted with EtOAc (2*50 mL). The organic extracts were washed with brine and the organic layer was dried over Na₂SO₄. It was filtered and the solvent was removed in vacuo to obtain (+)-2-amino-2-(3,4-difluorophenyl)-ethanol as a white solid (0.21 g, 87% yield).

References:

US6218390,2001,B1