ChemicalBook CAS DataBase List 4-(((tert-Butoxycarbonyl)amino)methyl)bicyclo[2.2.2]octane-1-carboxylicacid

4-(((tert-Butoxycarbonyl)amino)methyl)bicyclo[2.2.2]octane-1-carboxylicacid synthesis

3synthesis methods

Product Name:4-(((tert-Butoxycarbonyl)amino)methyl)bicyclo[2.2.2]octane-1-carboxylicacid
CAS Number:219996-49-3
Molecular formula:C15H25NO4
Molecular Weight:283.36

Bicyclo[2.2.2]octane-1-carboxylic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, methyl ester

916210-10-1
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4-(((tert-Butoxycarbonyl)amino)methyl)bicyclo[2.2.2]octane-1-carboxylicacid

219996-49-3
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$454.81/5MG

Yield:219996-49-3 56%

Reaction Conditions:

with potassium hydroxide;water for 15 h;Heating / reflux;

Steps:

42.A

To a solution of the title compound from the Preparative Example 41, Step A (2.0 g) in MeOH (10 mL) was added a solution of KOH (753 mg) in H₂O (2 mL). The mixture was heated to reflux for 15 h, concentrated to approximately half of its volume and diluted with H₂O (50 mL). EtOAc (100 mL) was added and the organic phase was separated. The aqueous phase was acidified to pH 4.5 and extracted with EtOAc (3 x 40 mL). The combined organic phases were washed with saturated aqueous NaCl (50 mL), dried (MgSO₄), filtered and concentrated to afford the title compound (1.1 g, 56%). [MNa]⁺ = 306.

References:

WO2006/128184,2006,A2 Location in patent:Page/Page column 166-167

4-(aminomethyl)bicyclo[2.2.2]octane-1-carboxylic acid hydrochloride

24238-86-6
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219996-49-3
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$454.81/5MG

References

24238-86-6
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7732-18-5
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219996-49-3
16 suppliers
$454.81/5MG

References