![](/CAS/20130318/GIF/CB82599546.gif)
(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid synthesis
- Product Name:(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
- CAS Number:220352-36-3
- Molecular formula:C10H8F2O2
- Molecular Weight:198.17
![Triethyl phosphonoacetate](/CAS/GIF/867-13-0.gif)
867-13-0
462 suppliers
$10.00/1g
![(1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol](/CAS/GIF/1006376-60-8.gif)
1006376-60-8
107 suppliers
inquiry
![(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid](/CAS/20130318/GIF/CB82599546.gif)
220352-36-3
107 suppliers
inquiry
Yield:220352-36-3 87%
Reaction Conditions:
with potassium tert-butylate in toluene at 30 - 50; for 30 h;Temperature;
Steps:
6 Example 6: Specific preparation of the compound of formula VII (1R, 2R) -2- (3,4-difluorophenyl) cyclopropanoic acid
Potassium tert-butoxide (4.3 g, 64 mmol) was added 40 ml of toluene, A solution of the compound of formula VIII, phosphonoethyl triethyl ester (11.4 g, 51.2 mmol) was added dropwise at a temperature of 30 ° C, Drop finished, A solution of the compound of formula IV (S) -2-chloro-1- (3,4-difluorophenyl) ethanol (2.46 g, 12.8 mmol) in 12 ml of toluene was added dropwise, Insulation 40 ~ 50 reaction 30 hours, Add 20 ml of water, Divide the water phase. Add 5 ml of toluene, 6 ml of methanol, 5 ml of 30% sodium hydroxide solution, 65 ° C for 1.5 hours. Spin the solvent, Add 20 ml of water, Toluene 20 ml, extraction, Points to oil phase, Water with concentrated hydrochloric acid to adjust the pH value of 2 to 3, Plus toluene 20 ml extraction, Oil phase dry, Spin dry 2.22 g of the compound of formula VII, Quickly after curing. Yield 87%.
References:
Shangyu Jing Xin Pharmaceutical Co., Ltd.;Shanghai Jingxin Bio-pharmaceutical Co., Ltd.;Huang Yue;Xu Miaohuan CN104744266, 2017, B Location in patent:Paragraph 0066; 0067; 0068; 0069; 0070; 0071; 0072-0081
![(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonitrile](/CAS/20180906/GIF/1450916-28-5.gif)
1450916-28-5
1 suppliers
inquiry
![(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid](/CAS/20130318/GIF/CB82599546.gif)
220352-36-3
107 suppliers
inquiry
![(1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate](/CAS/GIF/1006376-61-9.gif)
1006376-61-9
64 suppliers
$55.00/5mg
![(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid](/CAS/20130318/GIF/CB82599546.gif)
220352-36-3
107 suppliers
inquiry
![1,2-Difluoro-4-iodobenzene](/CAS/GIF/64248-58-4.gif)
64248-58-4
194 suppliers
$14.00/5g
![Cyclopropanecarboxylic acid](/CAS/GIF/1759-53-1.gif)
1759-53-1
468 suppliers
$6.00/10g
![(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid](/CAS/20130318/GIF/CB82599546.gif)
220352-36-3
107 suppliers
inquiry
![3,4-Difluorobenzaldehyde](/CAS/GIF/34036-07-2.gif)
34036-07-2
352 suppliers
$7.00/5g
![(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid](/CAS/20130318/GIF/CB82599546.gif)
220352-36-3
107 suppliers
inquiry