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1H-INDOLE-3-ACETIC ACID, 6-BROMO-A-OXO-, METHYL ESTER synthesis

5synthesis methods
-

Yield:220407-33-0 58.9%

Reaction Conditions:

Stage #1: 6-bromo-1H-indole;oxalyl dichloride in diethyl ether at 0 - 5; for 1 h;
Stage #2: sodium methylate in methanol;diethyl ether at -30 - -20; for 0.5 h;

References:

Ye, Qing;Li, Meng;Zhou, Yu-Bo;Cao, Jia-Yu;Xu, Lei;Li, Yu-Jin;Han, Liang;Gao, Jian-Rong;Hu, Yong-Zhou;Li, Jia [Archiv der Pharmazie,2013,vol. 346,# 5,p. 349 - 358]