CIS-1,2-DIBORONO-1,2-DIPHENYLETHYLENE, DIPINACOL ESTER synthesis

Yield:221006-76-4 85%

Reaction Conditions:

with tetrakis(triphenylphosphine)platinum in N,N-dimethyl-formamide at 90; for 9 h;Inert atmosphere;Temperature;

Steps:

1.a; 2.a; 3.a; 4.a; 5.a

Step a, Add 10.2 g (40 mmol) of pinacol diborate and 0.25 g (0.2 mmol) tetrakis(triphenylphosphine)platinum is added to a dry reaction vessel containing 50 ml N,N-dimethylformamide and has a nitrogen.3.6 g (20 mmol) of diphenylacetylene was dissolved in 50 mL N,N-dimethylformamide,Manded into solution, dripped into the above reaction vessel, warmed to 90 ° C,The reaction was reacted at 90 ° C for 9 h, cooled to room temperature,Steam under reduced pressure to obtain a crude product solution of distyrylboronic acid pinacol ester,Take petroleum ether: dichloromethane = 2: 1 for column chromatography (fixed phase silica gel),The eluate is evaporated to remove the solvent by evaporation, resulting in 5.95 g of white needle solids.That is, a refined distyrylboronic acid pinacol ester, yield is 85%, and the purity is 98%.

References:

CN113307727,2021,A Location in patent:Paragraph 0028-0030; 0039-0041; 0050-0052; 0061-0063; ...