2-[(dimethylamino)methyl]-1,3-thiazole-4-carboxylic acid(SALTDATA: HCl) synthesis

2synthesis methods

Product Name:2-[(dimethylamino)methyl]-1,3-thiazole-4-carboxylic acid(SALTDATA: HCl)
CAS Number:221323-50-8
Molecular formula:C7H10N2O2S
Molecular Weight:186.23

ethyl 2-[(dimethylamino)methyl]thiazole-4-carboxylate

82586-66-1
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2-[(dimethylamino)methyl]-1,3-thiazole-4-carboxylic acid(SALTDATA: HCl)

221323-50-8
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Yield:-

Reaction Conditions:

Stage #1: ethyl 2-(dimethylaminomethyl)-4-thiazolecarboxylatewith lithium hydroxide in tetrahydrofuran;methanol at 20; for 3 h;
Stage #2: in tetrahydrofuran;methanol; pH=2;Acidic conditions;

Steps:

161.b

Ethyl 2-((dimethylamino)methyl)thiazole-4-carboxylate (147 mg, 0.686 mmol) was dissolved in THF/methanol mixture (9: 1) and 1M lithium hydroxide (1.372 ml, 1.372 mmol) was added slowly. The reaction mixture was stirred at RT for 3 h, pH was adjusted to 2 and the mixture was evaporated to dryness to yield the title compound as a crude product, m/z [ 186.2+ 1 ] .

References:

WO2011/51540,2011,A1 Location in patent:Page/Page column 137

Ethyl2-(chloromethyl)thiazole-4-carboxylate

842130-48-7
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$45.00/100mg

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References